From the experimental intracellular action potential to the clinical treatment based on human intracardiac electrophysiology (arrhythmia-surgery, ICD, transcatheter ablation)
Gottsegen György Országos Kardiológiai Intézet, Felnőtt Kardiológiai Osztály, Budapest
A short review is provided of the author’s medical carrier, which started at the Department of Pharmacology of Szeged Medical University (1970). In connection with the free fatty acid hypothesis, he studied the direct effects of the high free fatty acid level on the electrical activity of calf Purkinje fibres under the guidance of Julius Gy. Papp in the Working Group of Cardiac Electrophysiology. It was concluded that the electrical activity can be seriously altered by high free fatty acid level already in a normal Purkinje fibre. His clinical work, as a cardiologist, continued at the Hungarian Institute of Cardiology in Budapest (1976–). He became adept early at investigational methods of intracardiac electrophysiology besides his clinical works. Numerous new therapeutic approach has been introduced by him first in the country based on intracardiac electrophysiology. In 1990 they performed a successful arrhythmia-surgery in a patient with serious WPW syndrome, in 1992 they implanted the first ICD (VVICD) in the country, later in 1997 the first ICD of DDICD type. After the foundation of a transcatheter ablation laboratory (1994), he performed the first transcatheter ablation in a patient with serious WPW syndrome (1994), later he performed the first „slow-pathway” modification in AVNRT (1995).According to his opinion, his knowledge in cardiac microelectrophysiology learned in the years of Szeged and the continuous inspirations by his first university master went a long way towards the first therapeutic antiarrhythmic interventions in the country based on intracardiac electrophysiology.