Mechanism of the sinus node spontaneous automacy: chronicle of two decades of debate
Nagy Norbert1,2, Varró András1,2, Tóth András1,2
1MTA-SZTE Keringésfarmakológiai Kutatócsoport, Szeged
2SZTE-ÁOK, Farmakológiai és Farmakoterápiai Intézet, Szeged
The discovery of the exact mechanism of sinus node pacemaking process has initiated intensive research from 1950. Furthermore, the spontaneous automaticity is particular because it generated perhaps one the most interesting debate in the past three decade of experimental cardiology. During these years several dominating hypothesis were existing to explain the pacemaking mechanism, and then by the increasing number of the available experimental results have lead to several change of the actual paradigm. Several laboratories provided important result promoting the research, often generating intensive debates until getting to the current accepted view. The aim of this study is to summarize the most important milestones in the research of spontaneous automaticity, guiding the reader through the dominant hypothesis to the actual accepted concept.