The two decades of investigation of the slow delayed rectifier potassium current (IKs) and the repolarization reserve in the Department of Pharmacology and Pharmacotherapy, University of Szeged
Varró András1,2, Virág László2, Jost Norbert1,2
Szegedi Tudományegyetem, Általános Orvostudományi Kar,
1Farmakológiai és Farmakoterápiai Intézet,
2MTA-SZTE Keringésfarmakológiai Kutatócsoport, Szeged
The aim of this review is to present the key role of the slow component of the delayed rectifier potassium current (IKs) and the repolarization reserve in large mammalians including human ventricle. The review gives a detailed historical description about how our group identified and gave the first experimental demonstration about the cardiac repolarization reserve. The authors also present the role of the IKs current in the human cardiac repolarization and repolarization reserve focusing on several pathophysiological situations, such as genetic diseases (for example LQT syndromes), diabetes mellitus, congestive heart failure and the serious lethal ventricular arrhythmias (for example Torsade de Pointes cardiac arrhythmias).