Direct anticoagulants in the daily practice. Results of the ARISTOPHANES study
Pécsi Tudományegyetem Klinikai Központ, Szívgyógyászati Klinika, Pécs
The ARISTOPHANES retrospective observational study compared stroke / systemic embolization and severe bleeding in a large number of patients treated with direct, non-vitamin K antagonist oral anticoagulants or warfarin using an extentensive set of data sources. In the largest observational study to date with DOACs and warfarin, lower stroke / SE and variable bleeding rates were confirmed with DOACs compared to warfarin. These provide additional data to balance the risk of thromboembolism and bleeding in therapeutic decision-making.