A new chapter in blood pressure reduction: a distinction between thiazide-type and thiazide-like diuretics
Semmelweis Egyetem, Általános Orvostudományi Kar, Belgyógyászati és Hematológiai Klinika, Budapest
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In the last four-five years, several evidence-based, national, and international guidelines on the management of arterial hypertension have been published, mostly with concordant recommendations, but in some aspects with discordant opinions. Simplified antihypertensive drug treatment such as single-pill combinations enhances the adherence to medication and speeds up the process of getting into the blood pressure target range, a goal not so far adequately respected. The single-pill combination therapy may contain diuretics as part of the first step of antihypertensive therapy. Because there are clinically significant differences in the efficacy and safety profile of diuretics, several guidelines differentiate between thiazide-type and thiazide-like diuretics. Studies suggest that thiazide-like diuretics reduce blood pressure more strongly, and provide greater cardiovascular protection than thiazide-type diuretics.