Pharmacological possibilities of testing TRPM4 ion channels

█ Review

DOI: 10.26430/CHUNGARICA.2023.53.5.446

Authors:
Dienes Csaba Bálint^1,2, Kovács Zsigmond Máté^1,2, Óvári József^1,3, Szentandrássy Norbert^1,4
1Debreceni Egyetem, ÁOK, Élettani Intézet, Debrecen
²Debreceni Egyetem, Molekuláris Orvostudomány Doktori Iskola, Debrecen
³Debreceni Egyetem, Fogorvostudományi Doktori Iskola, Debrecen
⁴Debreceni Egyetem, FOK, Alapozó Orvosi Ismeretek Intézet, Debrecen

 

Summary

The Transient Receptor Potential Melastatin 4 is a unique member of the TRPM protein family. Like TRPM5, it is Ca2+-sensitive and permeable only to monovalent cations. It is widely expressed in many organs and has multiple functions in both excitable and non-excitable cells by regulating membrane potential and Ca2+ homeostasis. This review discusses the pharmacological modulation of TRPM4 by comparing and describing one older, more commonly used inhibitor of the ion channel and two newer, potentially more selective inhibitors. TRPM4 is receiving increasing attention and is likely to be a topic of future research.

ISSUE: CARDIOLOGIA HUNGARICA | 2023 | VOLUME 53, ISSUE 5

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