Chronic heart failure and type 2 diabetes
Tihanyi László, Veress Gábor
Állami Szívkórház, Balatonfüred
This summary discusses the coincidence of chronic heart failure and type 2 diabetes. Based on the literature, we present the therapeutic possibilities from the aspect of type 2 diabetes that is available today.
Diabetic cardiomyopathy is a distinct clinical entity. Neither the hypertonia nor the narrowing of the epicardial coronary arteries are involved in its development. Myocardial dysfunction is due to microangiopathic myocyte hypoxia, glucotoxicity and lipotoxicity.
The use of sulfonylurea and insulin is not optimal with regard to safety in patients with circulatory insufficiency. The new type of antidiabetics are cardiovascularly safe, GLP-1 analogues and SGLT-2 inhibitors significantly reduced hospitalization and total mortality connected to heart failure.