The microbiome and cardiovascular health

█ Review

DOI: 10.26430/CHUNGARICA.2024.54.1.32

Authors:
Péterfi Zoltán
Pécsi Tudományegyetem, Klinikai Központ, I. sz. Belgyógyászati Klinika, Infektológiai Tanszék, Pécs

Summary
The gut microbiome plays an important role in the development or evolution of several diseases. An area less known is the relationship between cardiovascular diseases and the microbiome, the relationship between the gut-heart axis and atherosclerosis. Lipopolysaccharide, trimethylamine, phenylacetyl glutamine, short-chain fatty acids, and secondary biliary acids are just a few of the intermediary molecules that the intestinal microbiome uses to exert its influence. Most of the effects are not direct, but rather through changes in metabolic processes and are the result of a long-lasting process, which is why it is difficult to examine them and prove the correlations. Stopping or reversing the pathological processes can be achieved by restoring the balance of the gut microbiome. In this article, we summarize our knowledge so far about the effect of the metabolic products of the microbiome on the cardiovascular system, as well as the options available to us in order to prevent their pathological effects.

ISSUE: CARDIOLOGIA HUNGARICA | 2024 | VOLUME 54, ISSUE 1

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